Inhibition of O-GlcNAc transferase activity reprograms prostate cancer cell metabolism

Metabolic networks are highly connected and complex, but a single enzyme, O-GlcNAc transferase (OGT) can sense the availability of metabolites and also modify target proteins. We show that inhibition of OGT activity inhibits the proliferation of prostate cancer cells, leads to sustained loss of c-MY...

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Detalles Bibliográficos
Autores principales: Itkonen, Harri M., Gorad, Saurabh S., Duveau, Damien Y., Martin, Sara E.S., Barkovskaya, Anna, Bathen, Tone F., Moestue, Siver A., Mills, Ian G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914298/
https://www.ncbi.nlm.nih.gov/pubmed/26824323
http://dx.doi.org/10.18632/oncotarget.7039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914298/
https://www.ncbi.nlm.nih.gov/pubmed/26824323
http://dx.doi.org/10.18632/oncotarget.7039

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