Cargando…
Inhibition of O-GlcNAc transferase activity reprograms prostate cancer cell metabolism
Metabolic networks are highly connected and complex, but a single enzyme, O-GlcNAc transferase (OGT) can sense the availability of metabolites and also modify target proteins. We show that inhibition of OGT activity inhibits the proliferation of prostate cancer cells, leads to sustained loss of c-MY...
Autores principales: | Itkonen, Harri M., Gorad, Saurabh S., Duveau, Damien Y., Martin, Sara E.S., Barkovskaya, Anna, Bathen, Tone F., Moestue, Siver A., Mills, Ian G. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914298/ https://www.ncbi.nlm.nih.gov/pubmed/26824323 http://dx.doi.org/10.18632/oncotarget.7039 |
Ejemplares similares
-
O-GlcNAc Transferase Inhibition Differentially Affects Breast Cancer Subtypes
por: Barkovskaya, Anna, et al.
Publicado: (2019) -
Inhibition of O-GlcNAc transferase activates tumor-suppressor gene expression in tamoxifen-resistant breast cancer cells
por: Barkovskaya, Anna, et al.
Publicado: (2020) -
O-GlcNAc transferase maintains metabolic homeostasis in response to CDK9 inhibition
por: Gondane, Aishwarya, et al.
Publicado: (2022) -
O-GlcNAc transferase couples MRE11 to transcriptionally active chromatin to suppress DNA damage
por: Gondane, Aishwarya, et al.
Publicado: (2022) -
X-inactivation normalizes O-GlcNAc transferase levels and generates an O-GlcNAc-depleted Barr body
por: Olivier-Van Stichelen, Stéphanie, et al.
Publicado: (2014)