Loss of MEN1 activates DNMT1 implicating DNA hypermethylation as a driver of MEN1 tumorigenesis

Multiple endocrine neoplasia type 1 (MEN1) syndrome results from mutations in the MEN1 gene and causes tumor formation via largely unknown mechanisms. Using a novel genome-wide methylation analysis, we studied tissues from MEN1-parathyroid tumors, Men1 knockout (KO) mice, and Men1 null mouse embryon...

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Detalles Bibliográficos
Autores principales: Yuan, Ziqiang, Claros, Carmen Sánchez, Suzuki, Masako, Maggi, Elaine C., Kaner, Justin D., Kinstlinger, Noah, Gorecka, Jolanta, Quinn, Thomas J., Geha, Rula, Corn, Amanda, Pastoriza, Jessica, Jing, Qiang, Adem, Asha, Wu, Hao, Alemu, Girum, Du, Yi-Chieh, Zheng, Deyou, Greally, John M., Libutti, Steven K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914310/
https://www.ncbi.nlm.nih.gov/pubmed/26871472
http://dx.doi.org/10.18632/oncotarget.7279

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914310/
https://www.ncbi.nlm.nih.gov/pubmed/26871472
http://dx.doi.org/10.18632/oncotarget.7279

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