Inhibition of deubiquitinases primes glioblastoma cells to apoptosis in vitro and in vivo

It remains a challenge in oncology to identify novel drug regimens to efficiently tackle glioblastoma, the most common primary brain tumor in adults. Here, we target deubiquitinases for glioblastoma therapy by utilizing the small-molecule inhibitor WP1130 which has been characterized as a deubiquiti...

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Detalles Bibliográficos
Autores principales: Karpel-Massler, Georg, Banu, Matei A., Shu, Chang, Halatsch, Marc-Eric, Westhoff, Mike-Andrew, Bruce, Jeffrey N., Canoll, Peter, Siegelin, Markus D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914322/
https://www.ncbi.nlm.nih.gov/pubmed/26872380
http://dx.doi.org/10.18632/oncotarget.7302

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914322/
https://www.ncbi.nlm.nih.gov/pubmed/26872380
http://dx.doi.org/10.18632/oncotarget.7302

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