Multi-kinase inhibitors can associate with heat shock proteins through their NH(2)-termini by which they suppress chaperone function

We performed proteomic studies using the GRP78 chaperone-inhibitor drug AR-12 (OSU-03012) as bait. Multiple additional chaperone and chaperone-associated proteins were shown to interact with AR-12, including: GRP75, HSP75, BAG2; HSP27; ULK-1; and thioredoxin. AR-12 down-regulated in situ immuno-fluo...

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Detalles Bibliográficos
Autores principales: Booth, Laurence, Shuch, Brian, Albers, Thomas, Roberts, Jane L., Tavallai, Mehrad, Proniuk, Stefan, Zukiwski, Alexander, Wang, Dasheng, Chen, Ching-Shih, Bottaro, Don, Ecroyd, Heath, Lebedyeva, Iryna O., Dent, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914336/
https://www.ncbi.nlm.nih.gov/pubmed/26887051
http://dx.doi.org/10.18632/oncotarget.7349

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914336/
https://www.ncbi.nlm.nih.gov/pubmed/26887051
http://dx.doi.org/10.18632/oncotarget.7349

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