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Regulation of ribosomal RNA expression across the lifespan is fine-tuned by maternal diet before implantation

Cells and organisms respond to nutrient deprivation by decreasing global rates of transcription, translation and DNA replication. To what extent such changes can be reversed is largely unknown. We examined the effect of maternal dietary restriction on RNA synthesis in the offspring. Low protein diet...

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Detalles Bibliográficos
Autores principales: Denisenko, Oleg, Lucas, Emma S., Sun, Congshan, Watkins, Adam J., Mar, Daniel, Bomsztyk, Karol, Fleming, Tom P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Pub. Co 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914606/
https://www.ncbi.nlm.nih.gov/pubmed/27060415
http://dx.doi.org/10.1016/j.bbagrm.2016.04.001