A new autoinhibited kinase conformation reveals a salt-bridge switch in kinase activation

In the structure of autoinhibited EphA2 tyrosine kinase reported herein, we have captured the entire activation segment, revealing a previously unknown role of the conserved Arg762 in kinase autoinhibition by interacting with the essential Mg(2+)-chelating Asp757. While it is well known that this Ar...

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Detalles Bibliográficos
Autores principales: Wei, Qiang, Yang, Shaoyuan, Li, Dan, Zhang, Xiaoying, Zheng, Jimin, Jia, Zongchao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914941/
https://www.ncbi.nlm.nih.gov/pubmed/27324091
http://dx.doi.org/10.1038/srep28437

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914941/
https://www.ncbi.nlm.nih.gov/pubmed/27324091
http://dx.doi.org/10.1038/srep28437

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