Down-regulation of HSP60 Suppresses the Proliferation of Glioblastoma Cells via the ROS/AMPK/mTOR Pathway

Glioblastoma is a fatal and incurable cancer with the hyper-activated mTOR pathway. HSP60, a major chaperone for maintenance of mitochondrial proteostasis, is highly expressed in glioblastoma patients. To understand the effects of HSP60 on glioblastoma tumorigenesis and progression, we characterized...

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Detalles Bibliográficos
Autores principales: Tang, Haiping, Li, Jin, Liu, Xiaohui, Wang, Guihuai, Luo, Minkui, Deng, Haiteng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914999/
https://www.ncbi.nlm.nih.gov/pubmed/27325206
http://dx.doi.org/10.1038/srep28388

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914999/
https://www.ncbi.nlm.nih.gov/pubmed/27325206
http://dx.doi.org/10.1038/srep28388

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