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Comparative analysis of individual chromosome involvement in micronuclei induced by mitomycin C and bleomycin in human leukocytes

BACKGROUND: Micronucleus (MN) assay is a well standardized approach for evaluation of clastogenic/aneugenic effects of mutagens. Fluorescence in situ hybridization (FISH) is successfully used to characterize the chromosomal content of MN. However, the relationships between nuclear positioning, lengt...

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Detalles Bibliográficos
Autores principales: Hovhannisyan, Galina, Aroutiounian, Rouben, Babayan, Nelly, Harutyunyan, Tigran, Liehr, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915088/
https://www.ncbi.nlm.nih.gov/pubmed/27330564
http://dx.doi.org/10.1186/s13039-016-0258-4