Cargando…
Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies
Telomeres maintain genomic integrity in normal cells, and their progressive shortening during successive cell divisions induces chromosomal instability. In the large majority of cancer cells, telomere length is maintained by telomerase. Thus, telomere length and telomerase activity are crucial for c...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2016
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915101/ https://www.ncbi.nlm.nih.gov/pubmed/27323951 http://dx.doi.org/10.1186/s13073-016-0324-x |