Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer

Cancer cells often require glutamine for growth, thereby distinguishing them from most normal cells. Here we show that PIK3CA mutations reprogram glutamine metabolism by upregulating glutamate pyruvate transaminase 2 (GPT2) in colorectal cancer (CRC) cells, making them more dependent on glutamine. C...

Descripción completa

Detalles Bibliográficos
Autores principales: Hao, Yujun, Samuels, Yardena, Li, Qingling, Krokowski, Dawid, Guan, Bo-Jhih, Wang, Chao, Jin, Zhicheng, Dong, Bohan, Cao, Bo, Feng, Xiujing, Xiang, Min, Xu, Claire, Fink, Stephen, Meropol, Neal J., Xu, Yan, Conlon, Ronald A., Markowitz, Sanford, Kinzler, Kenneth W., Velculescu, Victor E., Brunengraber, Henri, Willis, Joseph E., LaFramboise, Thomas, Hatzoglou, Maria, Zhang, Guo-Fang, Vogelstein, Bert, Wang, Zhenghe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915131/
https://www.ncbi.nlm.nih.gov/pubmed/27321283
http://dx.doi.org/10.1038/ncomms11971

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915131/
https://www.ncbi.nlm.nih.gov/pubmed/27321283
http://dx.doi.org/10.1038/ncomms11971

Ejemplares similares