Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3

Targeting mTORC1 is a highly promising strategy in cancer therapy. Suppression of mTORC1 activity leads to rapid dephosphorylation of eIF4E-binding proteins (4E-BP1–3) and subsequent inhibition of mRNA translation. However, how the different 4E-BPs affect translation during prolonged use of mTOR inh...

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Detalles Bibliográficos
Autores principales: Tsukumo, Yoshinori, Alain, Tommy, Fonseca, Bruno D., Nadon, Robert, Sonenberg, Nahum
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915159/
https://www.ncbi.nlm.nih.gov/pubmed/27319316
http://dx.doi.org/10.1038/ncomms11776

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915159/
https://www.ncbi.nlm.nih.gov/pubmed/27319316
http://dx.doi.org/10.1038/ncomms11776

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