SUMOylation of DNA topoisomerase IIα regulates histone H3 kinase Haspin and H3 phosphorylation in mitosis

DNA topoisomerase II (TOP2) plays a pivotal role in faithful chromosome separation through its strand-passaging activity that resolves tangled genomic DNA during mitosis. Additionally, TOP2 controls progression of mitosis by activating cell cycle checkpoints. Recent work showed that the enzymaticall...

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Detalles Bibliográficos
Autores principales: Yoshida, Makoto M., Ting, Lily, Gygi, Steven P., Azuma, Yoshiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915188/
https://www.ncbi.nlm.nih.gov/pubmed/27325792
http://dx.doi.org/10.1083/jcb.201511079

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915188/
https://www.ncbi.nlm.nih.gov/pubmed/27325792
http://dx.doi.org/10.1083/jcb.201511079

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