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Impaired burrowing is the most prominent behavioral deficit of aging htau mice

htau mice are deficient of murine tau but express all six human tau isoforms, leading to gradual tau misprocessing and aggregation in brain areas relevant to Alzheimer’s disease. While histopathological changes in htau mice have been researched in the past, we focused here on functional consequences...

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Detalles Bibliográficos
Autores principales: Geiszler, Philippine Camilla, Barron, Matthew Richard, Pardon, Marie-Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915442/
https://www.ncbi.nlm.nih.gov/pubmed/27167086
http://dx.doi.org/10.1016/j.neuroscience.2016.05.004