Brain Insulin Signaling Is Increased in Insulin-Resistant States and Decreases in FOXOs and PGC-1α and Increases in Aβ(1–40/42) and Phospho-Tau May Abet Alzheimer Development

Increased coexistence of Alzheimer disease (AD) and type 2 diabetes mellitus (T2DM) suggests that insulin resistance abets neurodegenerative processes, but linkage mechanisms are obscure. Here, we examined insulin signaling factors in brains of insulin-resistant high-fat–fed mice, ob/ob mice, mice w...

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Detalles Bibliográficos
Autores principales: Sajan, Mini, Hansen, Barbara, Ivey, Robert, Sajan, Joshua, Ari, Csilla, Song, Shijie, Braun, Ursula, Leitges, Michael, Farese-Higgs, Margaret, Farese, Robert V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2016
Materias:
Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915579/
https://www.ncbi.nlm.nih.gov/pubmed/26895791
http://dx.doi.org/10.2337/db15-1428

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915579/
https://www.ncbi.nlm.nih.gov/pubmed/26895791
http://dx.doi.org/10.2337/db15-1428

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