Id2 reinforces T(H)1 cell differentiation and inhibits E2A to repress T(FH) cell differentiation

Differentiation of T helper (T(H)) effector subsets is critical for host protection. E protein transcription factors and Id proteins are important arbiters of T cell development, but their role in differentiation of T(H)1 and T(FH) cells is not well understood. T(H)1 cells showed robust Id2 expressi...

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Autores principales: Shaw, Laura A., Bélanger, Simon, Omilusik, Kyla D., Cho, Sunglim, Scott-Browne, James P., Nance, J. Philip, Goulding, John, Lasorella, Anna, Lu, Li-Fan, Crotty, Shane, Goldrath, Ananda W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915968/
https://www.ncbi.nlm.nih.gov/pubmed/27213691
http://dx.doi.org/10.1038/ni.3461
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author Shaw, Laura A.
Bélanger, Simon
Omilusik, Kyla D.
Cho, Sunglim
Scott-Browne, James P.
Nance, J. Philip
Goulding, John
Lasorella, Anna
Lu, Li-Fan
Crotty, Shane
Goldrath, Ananda W.
author_facet Shaw, Laura A.
Bélanger, Simon
Omilusik, Kyla D.
Cho, Sunglim
Scott-Browne, James P.
Nance, J. Philip
Goulding, John
Lasorella, Anna
Lu, Li-Fan
Crotty, Shane
Goldrath, Ananda W.
author_sort Shaw, Laura A.
collection PubMed
description Differentiation of T helper (T(H)) effector subsets is critical for host protection. E protein transcription factors and Id proteins are important arbiters of T cell development, but their role in differentiation of T(H)1 and T(FH) cells is not well understood. T(H)1 cells showed robust Id2 expression compared to T(FH) cells, and RNAi depletion of Id2 increased T(FH) cell frequencies. Further, T(H)1 cell differentiation was blocked by Id2 deficiency, leading to E protein-dependent accumulation of effector cells with mixed characteristics during viral infection and severely impaired generation of T(H)1 cells following Toxoplasma gondii infection. The T(FH)-defining transcriptional repressor Bcl6 bound the Id2 locus, providing a mechanism for the bimodal Id2 expression and reciprocal development of T(H)1 and T(FH) cell fates.
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spelling pubmed-49159682016-11-23 Id2 reinforces T(H)1 cell differentiation and inhibits E2A to repress T(FH) cell differentiation Shaw, Laura A. Bélanger, Simon Omilusik, Kyla D. Cho, Sunglim Scott-Browne, James P. Nance, J. Philip Goulding, John Lasorella, Anna Lu, Li-Fan Crotty, Shane Goldrath, Ananda W. Nat Immunol Article Differentiation of T helper (T(H)) effector subsets is critical for host protection. E protein transcription factors and Id proteins are important arbiters of T cell development, but their role in differentiation of T(H)1 and T(FH) cells is not well understood. T(H)1 cells showed robust Id2 expression compared to T(FH) cells, and RNAi depletion of Id2 increased T(FH) cell frequencies. Further, T(H)1 cell differentiation was blocked by Id2 deficiency, leading to E protein-dependent accumulation of effector cells with mixed characteristics during viral infection and severely impaired generation of T(H)1 cells following Toxoplasma gondii infection. The T(FH)-defining transcriptional repressor Bcl6 bound the Id2 locus, providing a mechanism for the bimodal Id2 expression and reciprocal development of T(H)1 and T(FH) cell fates. 2016-05-23 2016-07 /pmc/articles/PMC4915968/ /pubmed/27213691 http://dx.doi.org/10.1038/ni.3461 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Shaw, Laura A.
Bélanger, Simon
Omilusik, Kyla D.
Cho, Sunglim
Scott-Browne, James P.
Nance, J. Philip
Goulding, John
Lasorella, Anna
Lu, Li-Fan
Crotty, Shane
Goldrath, Ananda W.
Id2 reinforces T(H)1 cell differentiation and inhibits E2A to repress T(FH) cell differentiation
title Id2 reinforces T(H)1 cell differentiation and inhibits E2A to repress T(FH) cell differentiation
title_full Id2 reinforces T(H)1 cell differentiation and inhibits E2A to repress T(FH) cell differentiation
title_fullStr Id2 reinforces T(H)1 cell differentiation and inhibits E2A to repress T(FH) cell differentiation
title_full_unstemmed Id2 reinforces T(H)1 cell differentiation and inhibits E2A to repress T(FH) cell differentiation
title_short Id2 reinforces T(H)1 cell differentiation and inhibits E2A to repress T(FH) cell differentiation
title_sort id2 reinforces t(h)1 cell differentiation and inhibits e2a to repress t(fh) cell differentiation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915968/
https://www.ncbi.nlm.nih.gov/pubmed/27213691
http://dx.doi.org/10.1038/ni.3461
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