Transcription Factor KLF2 in Dendritic Cells Downregulates Th2 Programming via the HIF-1α/Jagged2/Notch Axis

The adaptive immune response is tightly regulated by complex signals in dendritic cells (DCs). Although Th2 polarization is dictated by defined functional DC subsets, the molecular factors that govern the amplitude of these responses are not well understood. Krüppel-like factor 2 (KLF2) is a transcr...

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Detalles Bibliográficos
Autores principales: Xiong, Ye, Lingrel, Jerry B., Wüthrich, Marcel, Klein, Bruce S., Vasudevan, Neelakantan T., Jain, Mukesh K., George, Mariam, Deepe, George S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916374/
https://www.ncbi.nlm.nih.gov/pubmed/27302755
http://dx.doi.org/10.1128/mBio.00436-16

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916374/
https://www.ncbi.nlm.nih.gov/pubmed/27302755
http://dx.doi.org/10.1128/mBio.00436-16

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