Futures Challenges in Thyroid Hormone Signaling Research

The canonical pathway of thyroid hormone signaling involves its binding to nuclear receptors (TRs) acting directly on the transcription of a number of genes. Recent genome-wide studies revealed that chromatin occupancy by TR is not sufficient for transactivation of gene expression. Reciprocally, in...

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Detalles Bibliográficos
Autor principal: Flamant, Frédéric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916735/
https://www.ncbi.nlm.nih.gov/pubmed/27445973
http://dx.doi.org/10.3389/fendo.2016.00058
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author Flamant, Frédéric
author_facet Flamant, Frédéric
author_sort Flamant, Frédéric
collection PubMed
description The canonical pathway of thyroid hormone signaling involves its binding to nuclear receptors (TRs) acting directly on the transcription of a number of genes. Recent genome-wide studies revealed that chromatin occupancy by TR is not sufficient for transactivation of gene expression. Reciprocally, in some cases, DNA binding by TR may not be required for cellular response. This leaves many new questions to be addressed in future research.
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spelling pubmed-49167352016-07-21 Futures Challenges in Thyroid Hormone Signaling Research Flamant, Frédéric Front Endocrinol (Lausanne) Endocrinology The canonical pathway of thyroid hormone signaling involves its binding to nuclear receptors (TRs) acting directly on the transcription of a number of genes. Recent genome-wide studies revealed that chromatin occupancy by TR is not sufficient for transactivation of gene expression. Reciprocally, in some cases, DNA binding by TR may not be required for cellular response. This leaves many new questions to be addressed in future research. Frontiers Media S.A. 2016-06-22 /pmc/articles/PMC4916735/ /pubmed/27445973 http://dx.doi.org/10.3389/fendo.2016.00058 Text en Copyright © 2016 Flamant. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Flamant, Frédéric
Futures Challenges in Thyroid Hormone Signaling Research
title Futures Challenges in Thyroid Hormone Signaling Research
title_full Futures Challenges in Thyroid Hormone Signaling Research
title_fullStr Futures Challenges in Thyroid Hormone Signaling Research
title_full_unstemmed Futures Challenges in Thyroid Hormone Signaling Research
title_short Futures Challenges in Thyroid Hormone Signaling Research
title_sort futures challenges in thyroid hormone signaling research
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916735/
https://www.ncbi.nlm.nih.gov/pubmed/27445973
http://dx.doi.org/10.3389/fendo.2016.00058
work_keys_str_mv AT flamantfrederic futureschallengesinthyroidhormonesignalingresearch

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