An HSV-based library screen identifies PP1α as a negative TRPV1 regulator with analgesic activity in models of pain

Transient receptor potential vanilloid 1 (TRPV1) is a pronociceptive cation channel involved in persistent inflammatory and neuropathic pain. Herpes simplex virus (HSV) vector expression of TRPV1 causes cell death in the presence of capsaicin, thereby completely blocking virus replication. Here we d...

Descripción completa

Detalles Bibliográficos
Autores principales: Reinhart, Bonnie, Goins, William F, Harel, Asaff, Chaudhry, Suchita, Goss, James R, Yoshimura, Naoki, de Groat, William C, Cohen, Justus B, Glorioso, Joseph C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916946/
https://www.ncbi.nlm.nih.gov/pubmed/27382601
http://dx.doi.org/10.1038/mtm.2016.40

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916946/
https://www.ncbi.nlm.nih.gov/pubmed/27382601
http://dx.doi.org/10.1038/mtm.2016.40

Ejemplares similares