Systemically administered AAV9-sTRAIL combats invasive glioblastoma in a patient-derived orthotopic xenograft model

Adeno-associated virus (AAV) vectors expressing tumoricidal genes injected directly into brain tumors have shown some promise, however, invasive tumor cells are relatively unaffected. Systemic injection of AAV9 vectors provides widespread delivery to the brain and potentially the tumor/microenvironm...

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Detalles Bibliográficos
Autores principales: Crommentuijn, Matheus HW, Kantar, Rami, Noske, David P, Vandertop, W Peter, Badr, Christian E, Würdinger, Thomas, Maguire, Casey A, Tannous, Bakhos A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916948/
https://www.ncbi.nlm.nih.gov/pubmed/27382645
http://dx.doi.org/10.1038/mto.2016.17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916948/
https://www.ncbi.nlm.nih.gov/pubmed/27382645
http://dx.doi.org/10.1038/mto.2016.17

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