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Novel Computational Protocols for Functionally Classifying and Characterising Serine Beta-Lactamases

Beta-lactamases represent the main bacterial mechanism of resistance to beta-lactam antibiotics and are a significant challenge to modern medicine. We have developed an automated classification and analysis protocol that exploits structure- and sequence-based approaches and which allows us to propos...

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Detalles Bibliográficos
Autores principales: Lee, David, Das, Sayoni, Dawson, Natalie L., Dobrijevic, Dragana, Ward, John, Orengo, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917113/
https://www.ncbi.nlm.nih.gov/pubmed/27332861
http://dx.doi.org/10.1371/journal.pcbi.1004926