Chemical Modification of Influenza CD8+ T-Cell Epitopes Enhances Their Immunogenicity Regardless of Immunodominance

T cells are essential players in the defense against infection. By targeting the MHC class I antigen-presenting pathway with peptide-based vaccines, antigen-specific T cells can be induced. However, low immunogenicity of peptides poses a challenge. Here, we set out to increase immunogenicity of infl...

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Detalles Bibliográficos
Autores principales: Rosendahl Huber, Sietske K., Luimstra, Jolien J., van Beek, Josine, Hoppes, Rieuwert, Jacobi, Ronald H. J., Hendriks, Marion, Kapteijn, Kim, Ouwerkerk, Casper, Rodenko, Boris, Ovaa, Huib, de Jonge, Jørgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917206/
https://www.ncbi.nlm.nih.gov/pubmed/27333291
http://dx.doi.org/10.1371/journal.pone.0156462

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917206/
https://www.ncbi.nlm.nih.gov/pubmed/27333291
http://dx.doi.org/10.1371/journal.pone.0156462

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