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Activation of GCN2 kinase by ribosome stalling links translation elongation with translation initiation

Ribosome stalling during translation has recently been shown to cause neurodegeneration, yet the signaling pathways triggered by stalled elongation complexes are unknown. To investigate these pathways we analyzed the brain of C57BL/6J-Gtpbp2(nmf205)(-/-) mice in which neuronal elongation complexes a...

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Detalles Bibliográficos
Autores principales: Ishimura, Ryuta, Nagy, Gabor, Dotu, Ivan, Chuang, Jeffrey H, Ackerman, Susan L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917338/
https://www.ncbi.nlm.nih.gov/pubmed/27085088
http://dx.doi.org/10.7554/eLife.14295