'Mitochondrial energy imbalance and lipid peroxidation cause cell death in Friedreich's ataxia'

Friedreich's ataxia (FRDA) is an inherited neurodegenerative disease. The mutation consists of a GAA repeat expansion within the FXN gene, which downregulates frataxin, leading to abnormal mitochondrial iron accumulation, which may in turn cause changes in mitochondrial function. Although, many...

Descripción completa

Detalles Bibliográficos
Autores principales: Abeti, R, Parkinson, M H, Hargreaves, I P, Angelova, P R, Sandi, C, Pook, M A, Giunti, P, Abramov, A Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917650/
https://www.ncbi.nlm.nih.gov/pubmed/27228352
http://dx.doi.org/10.1038/cddis.2016.111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917650/
https://www.ncbi.nlm.nih.gov/pubmed/27228352
http://dx.doi.org/10.1038/cddis.2016.111

Ejemplares similares