The impact of genetic polymorphisms on the pharmacokinetics of efavirenz in African children

AIMS: Using a model‐based approach, the efavirenz steady‐state pharmacokinetics in African children is characterized, quantifying demographic and genotypic effects on the drug's disposition. Simulations are also conducted allowing prediction of optimized doses of efavirenz in this population. M...

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Detalles Bibliográficos
Autores principales: Bienczak, Andrzej, Cook, Adrian, Wiesner, Lubbe, Olagunju, Adeniyi, Mulenga, Veronica, Kityo, Cissy, Kekitiinwa, Addy, Owen, Andrew, Walker, A. Sarah, Gibb, Diana M., McIlleron, Helen, Burger, David, Denti, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Paediatric Clinical Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917805/
https://www.ncbi.nlm.nih.gov/pubmed/26991336
http://dx.doi.org/10.1111/bcp.12934

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917805/
https://www.ncbi.nlm.nih.gov/pubmed/26991336
http://dx.doi.org/10.1111/bcp.12934

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