Metabolic and behavioral effects of mutant huntingtin deletion in Sim1 neurons in the BACHD mouse model of Huntington’s disease

Hypothalamic pathology, metabolic dysfunction and psychiatric symptoms are part of Huntington disease (HD), which is caused by an expanded CAG repeat in the huntingtin (HTT) gene. Inactivation of mutant HTT selectively in the hypothalamus prevents the development of metabolic dysfunction and depress...

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Detalles Bibliográficos
Autores principales: Soylu-Kucharz, Rana, Baldo, Barbara, Petersén, Åsa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917832/
https://www.ncbi.nlm.nih.gov/pubmed/27334347
http://dx.doi.org/10.1038/srep28322

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917832/
https://www.ncbi.nlm.nih.gov/pubmed/27334347
http://dx.doi.org/10.1038/srep28322

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