Cytochrome P450 metabolism of the post-lanosterol intermediates explains enigmas of cholesterol synthesis

Cholesterol synthesis is among the oldest metabolic pathways, consisting of the Bloch and Kandutch-Russell branches. Following lanosterol, sterols of both branches are proposed to be dedicated to cholesterol. We challenge this dogma by mathematical modeling and with experimental evidence. It was not...

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Detalles Bibliográficos
Autores principales: Ačimovič, Jure, Goyal, Sandeep, Košir, Rok, Goličnik, Marko, Perše, Martina, Belič, Ales, Urlep, Žiga, Guengerich, F. Peter, Rozman, Damjana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917857/
https://www.ncbi.nlm.nih.gov/pubmed/27334049
http://dx.doi.org/10.1038/srep28462

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917857/
https://www.ncbi.nlm.nih.gov/pubmed/27334049
http://dx.doi.org/10.1038/srep28462

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