TCF7L1 Modulates Colorectal Cancer Growth by Inhibiting Expression of the Tumor-Suppressor Gene EPHB3

Dysregulation of the Wnt pathway leading to accumulation of β-catenin (CTNNB1) is a hallmark of colorectal cancer (CRC). Nuclear CTNNB1 acts as a transcriptional coactivator with TCF/LEF transcription factors, promoting expression of a broad set of target genes, some of which promote tumor growth. H...

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Detalles Bibliográficos
Autores principales: Murphy, Matthew, Chatterjee, Sujash S., Jain, Sidharth, Katari, Manpreet, DasGupta, Ramanuj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917863/
https://www.ncbi.nlm.nih.gov/pubmed/27333864
http://dx.doi.org/10.1038/srep28299

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917863/
https://www.ncbi.nlm.nih.gov/pubmed/27333864
http://dx.doi.org/10.1038/srep28299

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