Rare disruptive mutations and their contribution to the heritable risk of colorectal cancer

Colorectal cancer (CRC) displays a complex pattern of inheritance. It is postulated that much of the missing heritability of CRC is enshrined in high-impact rare alleles, which are mechanistically and clinically important. In this study, we assay the impact of rare germline mutations on CRC, analysi...

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Detalles Bibliográficos
Autores principales: Chubb, Daniel, Broderick, Peter, Dobbins, Sara E., Frampton, Matthew, Kinnersley, Ben, Penegar, Steven, Price, Amy, Ma, Yussanne P., Sherborne, Amy L., Palles, Claire, Timofeeva, Maria N., Bishop, D. Timothy, Dunlop, Malcolm G., Tomlinson, Ian, Houlston, Richard S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917884/
https://www.ncbi.nlm.nih.gov/pubmed/27329137
http://dx.doi.org/10.1038/ncomms11883

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917884/
https://www.ncbi.nlm.nih.gov/pubmed/27329137
http://dx.doi.org/10.1038/ncomms11883

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