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Presynaptic muscarinic acetylcholine autoreceptors (M(1), M(2) and M(4) subtypes), adenosine receptors (A(1) and A(2A)) and tropomyosin-related kinase B receptor (TrkB) modulate the developmental synapse elimination process at the neuromuscular junction
BACKGROUND: The development of the nervous system involves an initially exuberant production of neurons that make an excessive number of synaptic contacts. The initial overproduction of synapses promotes connectivity. Hebbian competition between axons with different activities (the least active are...
Autores principales: | Nadal, Laura, Garcia, Neus, Hurtado, Erica, Simó, Anna, Tomàs, Marta, Lanuza, Maria A., Santafé, Manel, Tomàs, Josep |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917939/ https://www.ncbi.nlm.nih.gov/pubmed/27339059 http://dx.doi.org/10.1186/s13041-016-0248-9 |
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