ASC filament formation serves as a signal amplification mechanism for inflammasomes

A hallmark of inflammasome activation is the ASC speck, a micrometre-sized structure formed by the inflammasome adaptor protein ASC (apoptosis-associated speck-like protein containing a CARD), which consists of a pyrin domain (PYD) and a caspase recruitment domain (CARD). Here we show that assembly...

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Detalles Bibliográficos
Autores principales: Dick, Mathias S., Sborgi, Lorenzo, Rühl, Sebastian, Hiller, Sebastian, Broz, Petr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917984/
https://www.ncbi.nlm.nih.gov/pubmed/27329339
http://dx.doi.org/10.1038/ncomms11929

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917984/
https://www.ncbi.nlm.nih.gov/pubmed/27329339
http://dx.doi.org/10.1038/ncomms11929

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