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ASC filament formation serves as a signal amplification mechanism for inflammasomes
A hallmark of inflammasome activation is the ASC speck, a micrometre-sized structure formed by the inflammasome adaptor protein ASC (apoptosis-associated speck-like protein containing a CARD), which consists of a pyrin domain (PYD) and a caspase recruitment domain (CARD). Here we show that assembly...
Autores principales: | Dick, Mathias S., Sborgi, Lorenzo, Rühl, Sebastian, Hiller, Sebastian, Broz, Petr |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917984/ https://www.ncbi.nlm.nih.gov/pubmed/27329339 http://dx.doi.org/10.1038/ncomms11929 |
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