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An in vitro method for detecting genetic toxicity based on inhibition of RNA synthesis by DNA lesions
INTRODUCTION: A wide variety of DNA lesions such as ultraviolet light-induced photoproducts and chemically induced bulky adducts and crosslinks (intrastrand and interstrand) interfere with replication and lead to mutations and cell death. In the human body, these damages may cause cancer, inborn dis...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918014/ https://www.ncbi.nlm.nih.gov/pubmed/27350805 http://dx.doi.org/10.1186/s41021-015-0014-8 |