Cargando…

Alterations in the mutagenicity and mutation spectrum induced by benzo[a]pyrene instilled in the lungs of gpt delta mice of various ages

INTRODUCTION: To examine whether the mutagenic potential of lung exposure to air-borne environmental mutagens is age dependent, we administered 1 mg of benzo[a]pyrene intratracheally to 11- and 24-month old (middle-aged and old, respectively) gpt delta transgenic mice that harbor gpt (guanine phosph...

Descripción completa

Detalles Bibliográficos
Autores principales:	Aoki, Yasunobu, Hashimoto, Akiko H., Sugawara, Yoshiki, Hiyoshi-Arai, Kyoko, Goto, Sataro, Masumura, Kenichi, Nohmi, Takehiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918024/ https://www.ncbi.nlm.nih.gov/pubmed/27350804 http://dx.doi.org/10.1186/s41021-015-0004-x

Ejemplares similares

Change over time of the mutagenicity in the lungs of gpt delta transgenic mice by extract of airborne particles collected from ambient air in the Tokyo metropolitan area
por: Aoki, Yasunobu, et al.
Publicado: (2018)

New homozygous gpt delta transgenic rat strain improves an efficiency of the in vivo mutagenicity assay
por: Masumura, Kenichi, et al.
Publicado: (2021)

Characteristic mutations induced in the small intestine of Msh2-knockout gpt delta mice
por: Aoki, Yasunobu, et al.
Publicado: (2021)

Mutagenicity of carcinogenic heterocyclic amines in Salmonella typhimurium YG strains and transgenic rodents including gpt delta
por: Nohmi, Takehiko, et al.
Publicado: (2021)

Genomic integration of lambda EG10 transgene in gpt delta transgenic rodents
por: Masumura, Kenichi, et al.
Publicado: (2015)

Effects of the scid mutation on X-ray-induced deletions in the brain and spleen of gpt delta mice
por: Masumura, Kenichi, et al.
Publicado: (2020)

Estimation of the frequency of inherited germline mutations by whole exome sequencing in ethyl nitrosourea-treated and untreated gpt delta mice
por: Masumura, Kenichi, et al.
Publicado: (2016)

New Insight into Intrachromosomal Deletions Induced by Chrysotile in the gpt delta Transgenic Mutation Assay
por: Xu, An, et al.
Publicado: (2007)

Absence of in vivo mutagenicity of multi-walled carbon nanotubes in single intratracheal instillation study using F344 gpt delta rats
por: Horibata, Katsuyoshi, et al.
Publicado: (2017)

Integration of In Vivo Genotoxicity and Short-term Carcinogenicity Assays Using F344 gpt Delta Transgenic Rats: In Vivo Mutagenicity of 2,4-Diaminotoluene and 2,6-Diaminotoluene Structural Isomers
por: Toyoda-Hokaiwado, Naomi, et al.
Publicado: (2010)

Genotoxic responses to titanium dioxide nanoparticles and fullerene in gpt delta transgenic MEF cells
por: Xu, An, et al.
Publicado: (2009)

Mutant Frequency is not Increased in Mice Orally Exposed to Sodium Dichromate
por: Aoki, Yasunobu, et al.
Publicado: (2019)

Benzo(a)pyrene Is Mutagenic in Mouse Spermatogonial Stem Cells and Dividing Spermatogonia
por: O’Brien, Jason M., et al.
Publicado: (2016)

Validation study of the combined repeated-dose toxicity and genotoxicity assay using gpt delta rats
por: Akagi, Jun-ichi, et al.
Publicado: (2015)

Background data of 2-year-old male and female F344 gpt delta rats
por: Matsushita, Kohei, et al.
Publicado: (2020)

Presentation of benzo(a)pyrene to microsomal enzymes by asbestos fibers in the Salmonella/mammalian microsome mutagenicity test.
por: Szyba, K, et al.
Publicado: (1983)

PARP1 protects from benzo[a]pyrene diol epoxide-induced replication stress and mutagenicity
por: Fischer, Jan M. F., et al.
Publicado: (2017)

Development of a Medium-term Animal Model Using gpt Delta Rats to Evaluate Chemical Carcinogenicity and Genotoxicity
por: Matsushita, Kohei, et al.
Publicado: (2013)

DNA Polymerase Eta Participates in the Mutagenic Bypass of Adducts Induced by Benzo[a]pyrene Diol Epoxide in Mammalian Cells
por: Klarer, Alden C., et al.
Publicado: (2012)

Interaction of Thalassia testudinum Metabolites with Cytochrome P450 Enzymes and Its Effects on Benzo(a)pyrene-Induced Mutagenicity
por: Delgado-Roche, Livan, et al.
Publicado: (2020)

UVA Photoirradiation of Methylated Benzo[a]pyrene and Benzo[e]pyrene leading to Induction of Lipid Peroxidation
por: Sáenz, Diógenes Herreño, et al.
Publicado: (2007)

Bacillus subtilis is a Potential Degrader of Pyrene and Benzo[a]pyrene
por: Hunter, Rochelle D., et al.
Publicado: (2005)

Transgenic rat models for mutagenesis and carcinogenesis
por: Nohmi, Takehiko, et al.
Publicado: (2017)

Effect of sampling time on somatic and germ cell mutations induced by acrylamide in gpt delta mice
por: Hagio, Soichiro, et al.
Publicado: (2021)

Changes of biomarkers with oral exposure to benzo(a)pyrene, phenanthrene and pyrene in rats
por: Kang, Hwan Goo, et al.
Publicado: (2007)

Comparison of the frequencies of ENU-induced point mutations in male germ cells and inherited germline mutations in their offspring
por: Masumura, Kenichi, et al.
Publicado: (2021)

Free radicals of benzo(a)pyrene and derivatives.
por: Sullivan, P D
Publicado: (1985)

Radiation induced COX-2 expression and mutagenesis at non-targeted lung tissues of gpt delta transgenic mice
por: Chai, Y, et al.
Publicado: (2013)

Quantitation of exposure to benzo[a]pyrene with monoclonal antibodies.
por: Santella, R M, et al.
Publicado: (1985)

Influence of Benzo(a)pyrene on Different Epigenetic Processes
por: Bukowska, Bożena, et al.
Publicado: (2021)

Benzo[a]pyrene and Benzo[k]fluoranthene in Some Processed Fish and Fish Products
por: Olatunji, Olatunde S., et al.
Publicado: (2015)

NAD(P)H:quinone oxidoreductase 1 reduces the mutagenicity of DNA caused by NADPH:P450 reductase-activated metabolites of benzo(a)pyrene quinones.
por: Joseph, P., et al.
Publicado: (1998)

Assessment of Benzo(a)pyrene-equivalent Carcinogenicity and Mutagenicity of Residential Indoor versus Outdoor Polycyclic Aromatic Hydrocarbons Exposing Young Children in New York City
por: Jung, Kyung Hwa, et al.
Publicado: (2010)

Formation and persistence of benzo(a)pyrene metabolite-DNA adducts.
por: Stowers, S J, et al.
Publicado: (1985)

Chemoresistance to Cancer Treatment: Benzo-α-Pyrene as Friend or Foe?
por: Dzobo, Kevin, et al.
Publicado: (2018)

Modulatory Effects of Silymarin on Benzo[a]pyrene-Induced Hepatotoxicity
por: Jee, Seung-Cheol, et al.
Publicado: (2020)

Insight into the High-Efficiency Benzo(a)pyrene Degradation Ability of Pseudomonas benzopyrenica BaP3 and Its Application in the Complete Bioremediation of Benzo(a)pyrene
por: Dong, Xingchen, et al.
Publicado: (2023)

In vivo and in vitro mutagenicity of perillaldehyde and cinnamaldehyde
por: Honma, Masamitsu, et al.
Publicado: (2021)

Biotransformation of benzo[a]pyrene by Pannonibacter sp. JPA3 and the degradation mechanism through the initially oxidized benzo[a]pyrene-4,5-dihydrodiol to downstream metabolites
por: Jin, Jingnan, et al.
Publicado: (2023)

The carcinogenicity of some 6-substituted benzo(a)pyrene derivatives in mice.
por: Dewhurst, F., et al.
Publicado: (1972)

Cannot write session to /tmp/vufind_sessions/sess_j6rnilvuv7kdm6v65q79iacea9