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Inflammatory conditions partly impair the mechanically mediated activation of Smad2/3 signaling in articular cartilage

BACKGROUND: Joint trauma, which is frequently related with mechanical overloading of articular cartilage, is a well-established risk for osteoarthritis (OA) development. Additionally, reports show that trauma leads to synovial joint inflammation. In consequence, after joint trauma, cartilage is infl...

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Detalles Bibliográficos
Autores principales: Madej, Wojciech, Buma, Pieter, van der Kraan, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918093/
https://www.ncbi.nlm.nih.gov/pubmed/27334538
http://dx.doi.org/10.1186/s13075-016-1038-6