Estimation of the frequency of inherited germline mutations by whole exome sequencing in ethyl nitrosourea-treated and untreated gpt delta mice

BACKGROUND: Germline mutations are heritable and may cause health disadvantages in the next generation. To investigate trans-generational mutations, we treated male gpt delta mice with N-ethyl-N-nitrosourea (ENU) (85 mg/kg intraperitoneally, weekly on two occasions). The mice were mated with untreat...

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Detalles Bibliográficos
Autores principales: Masumura, Kenichi, Toyoda-Hokaiwado, Naomi, Ukai, Akiko, Gondo, Yoichi, Honma, Masamitsu, Nohmi, Takehiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918133/
https://www.ncbi.nlm.nih.gov/pubmed/27350829
http://dx.doi.org/10.1186/s41021-016-0035-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918133/
https://www.ncbi.nlm.nih.gov/pubmed/27350829
http://dx.doi.org/10.1186/s41021-016-0035-y

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