An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis

The evolutionary conserved NSL complex is a prominent epigenetic regulator controlling expression of thousands of genes. Here we uncover a novel function of the NSL complex members in mitosis. As the cell enters mitosis, KANSL1 and KANSL3 undergo a marked relocalisation from the chromatin to the mit...

Descripción completa

Detalles Bibliográficos
Autores principales: Meunier, Sylvain, Shvedunova, Maria, Van Nguyen, Nhuong, Avila, Leonor, Vernos, Isabelle, Akhtar, Asifa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918316/
https://www.ncbi.nlm.nih.gov/pubmed/26243146
http://dx.doi.org/10.1038/ncomms8889
_version_ 1782439102761664512
author Meunier, Sylvain
Shvedunova, Maria
Van Nguyen, Nhuong
Avila, Leonor
Vernos, Isabelle
Akhtar, Asifa
author_facet Meunier, Sylvain
Shvedunova, Maria
Van Nguyen, Nhuong
Avila, Leonor
Vernos, Isabelle
Akhtar, Asifa
author_sort Meunier, Sylvain
collection PubMed
description The evolutionary conserved NSL complex is a prominent epigenetic regulator controlling expression of thousands of genes. Here we uncover a novel function of the NSL complex members in mitosis. As the cell enters mitosis, KANSL1 and KANSL3 undergo a marked relocalisation from the chromatin to the mitotic spindle. By stabilizing microtubule minus ends in a RanGTP-dependent manner, they are essential for spindle assembly and chromosome segregation. Moreover, we identify KANSL3 as a microtubule minus-end-binding protein, revealing a new class of mitosis-specific microtubule minus-end regulators. By adopting distinct functions in interphase and mitosis, KANSL proteins provide a link to coordinate the tasks of faithful expression and inheritance of the genome during different phases of the cell cycle.
format Online
Article
Text
id pubmed-4918316
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-49183162016-07-07 An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis Meunier, Sylvain Shvedunova, Maria Van Nguyen, Nhuong Avila, Leonor Vernos, Isabelle Akhtar, Asifa Nat Commun Article The evolutionary conserved NSL complex is a prominent epigenetic regulator controlling expression of thousands of genes. Here we uncover a novel function of the NSL complex members in mitosis. As the cell enters mitosis, KANSL1 and KANSL3 undergo a marked relocalisation from the chromatin to the mitotic spindle. By stabilizing microtubule minus ends in a RanGTP-dependent manner, they are essential for spindle assembly and chromosome segregation. Moreover, we identify KANSL3 as a microtubule minus-end-binding protein, revealing a new class of mitosis-specific microtubule minus-end regulators. By adopting distinct functions in interphase and mitosis, KANSL proteins provide a link to coordinate the tasks of faithful expression and inheritance of the genome during different phases of the cell cycle. Nature Publishing Group 2015-08-05 /pmc/articles/PMC4918316/ /pubmed/26243146 http://dx.doi.org/10.1038/ncomms8889 Text en Copyright © 2015, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Meunier, Sylvain
Shvedunova, Maria
Van Nguyen, Nhuong
Avila, Leonor
Vernos, Isabelle
Akhtar, Asifa
An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis
title An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis
title_full An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis
title_fullStr An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis
title_full_unstemmed An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis
title_short An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis
title_sort epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918316/
https://www.ncbi.nlm.nih.gov/pubmed/26243146
http://dx.doi.org/10.1038/ncomms8889
work_keys_str_mv AT meuniersylvain anepigeneticregulatoremergesasmicrotubuleminusendbindingandstabilizingfactorinmitosis
AT shvedunovamaria anepigeneticregulatoremergesasmicrotubuleminusendbindingandstabilizingfactorinmitosis
AT vannguyennhuong anepigeneticregulatoremergesasmicrotubuleminusendbindingandstabilizingfactorinmitosis
AT avilaleonor anepigeneticregulatoremergesasmicrotubuleminusendbindingandstabilizingfactorinmitosis
AT vernosisabelle anepigeneticregulatoremergesasmicrotubuleminusendbindingandstabilizingfactorinmitosis
AT akhtarasifa anepigeneticregulatoremergesasmicrotubuleminusendbindingandstabilizingfactorinmitosis
AT meuniersylvain epigeneticregulatoremergesasmicrotubuleminusendbindingandstabilizingfactorinmitosis
AT shvedunovamaria epigeneticregulatoremergesasmicrotubuleminusendbindingandstabilizingfactorinmitosis
AT vannguyennhuong epigeneticregulatoremergesasmicrotubuleminusendbindingandstabilizingfactorinmitosis
AT avilaleonor epigeneticregulatoremergesasmicrotubuleminusendbindingandstabilizingfactorinmitosis
AT vernosisabelle epigeneticregulatoremergesasmicrotubuleminusendbindingandstabilizingfactorinmitosis
AT akhtarasifa epigeneticregulatoremergesasmicrotubuleminusendbindingandstabilizingfactorinmitosis

Ejemplares similares