IL10-driven STAT3 signalling in senescent macrophages promotes pathological eye angiogenesis

Macrophage dysfunction plays a pivotal role during neovascular proliferation in diseases of ageing including cancers, atherosclerosis and blinding eye disease. In the eye, choroidal neovascularization (CNV) causes blindness in patients with age-related macular degeneration (AMD). Here we report that...

Descripción completa

Detalles Bibliográficos
Autores principales: Nakamura, Rei, Sene, Abdoulaye, Santeford, Andrea, Gdoura, Abdelaziz, Kubota, Shunsuke, Zapata, Nicole, Apte, Rajendra S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918330/
https://www.ncbi.nlm.nih.gov/pubmed/26260587
http://dx.doi.org/10.1038/ncomms8847

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918330/
https://www.ncbi.nlm.nih.gov/pubmed/26260587
http://dx.doi.org/10.1038/ncomms8847

Ejemplares similares