MEF2B mutations in non-Hodgkin lymphoma dysregulate cell migration by decreasing MEF2B target gene activation

Myocyte enhancer factor 2B (MEF2B) is a transcription factor with mutation hotspots at K4, Y69 and D83 in diffuse large B-cell lymphoma (DLBCL). To provide insight into the regulatory network of MEF2B, in this study, we analyse global gene expression and DNA-binding patterns. We find that candidate...

Descripción completa

Detalles Bibliográficos
Autores principales: Pon, Julia R., Wong, Jackson, Saberi, Saeed, Alder, Olivia, Moksa, Michelle, Grace Cheng, S. -W., Morin, Gregg B., Hoodless, Pamela A., Hirst, Martin, Marra, Marco A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918335/
https://www.ncbi.nlm.nih.gov/pubmed/26245647
http://dx.doi.org/10.1038/ncomms8953

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918335/
https://www.ncbi.nlm.nih.gov/pubmed/26245647
http://dx.doi.org/10.1038/ncomms8953

Ejemplares similares