Structural basis for drug-induced allosteric changes to human β-cardiac myosin motor activity

Omecamtiv Mecarbil (OM) is a small molecule allosteric effector of cardiac myosin that is in clinical trials for treatment of systolic heart failure. A detailed kinetic analysis of cardiac myosin has shown that the drug accelerates phosphate release by shifting the equilibrium of the hydrolysis step...

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Detalles Bibliográficos
Autores principales: Winkelmann, Donald A., Forgacs, Eva, Miller, Matthew T., Stock, Ann M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918383/
https://www.ncbi.nlm.nih.gov/pubmed/26246073
http://dx.doi.org/10.1038/ncomms8974

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918383/
https://www.ncbi.nlm.nih.gov/pubmed/26246073
http://dx.doi.org/10.1038/ncomms8974

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