Functioning of Microsomal Cytochrome P450s: Murburn Concept Explains the Metabolism of Xenobiotics in Hepatocytes

Using oxygen and NADPH, the redox enzymes cytochrome P450 (CYP) and its reductase (CPR) work in tandem to carry out the phase I metabolism of a vast majority of drugs and xenobiotics. As per the erstwhile understanding of the catalytic cycle, binding of the substrate to CYP's heme distal pocket...

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Detalles Bibliográficos
Autores principales: Manoj, Kelath Murali, Parashar, Abhinav, Gade, Sudeep K., Venkatachalam, Avanthika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918403/
https://www.ncbi.nlm.nih.gov/pubmed/27445805
http://dx.doi.org/10.3389/fphar.2016.00161

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918403/
https://www.ncbi.nlm.nih.gov/pubmed/27445805
http://dx.doi.org/10.3389/fphar.2016.00161

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