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Presenilin adopts the ClC channel fold
Presenilin is an integral membrane aspartate protease that regulates cellular processes by cleaving proteins within the cell membrane. The recent crystal structure of presenilin reveals a conspicuous pore in a bundle of nine α‐helices, which was originally thought to adopt a novel protein fold. Howe...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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John Wiley and Sons Inc.
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918416/ https://www.ncbi.nlm.nih.gov/pubmed/26971579 http://dx.doi.org/10.1002/pro.2919 |