Dexmedetomidine attenuates repeated propofol exposure-induced hippocampal apoptosis, PI3K/Akt/Gsk-3β signaling disruption, and juvenile cognitive deficits in neonatal rats

Propofol is one of the most widely used intravenous anesthetics. However, repeated exposure to propofol may cause neurodegeneration in the developing brain. Dexmedetomidine (Dex), an α2 adrenoceptor agonist, has been previously demonstrated to provide neuroprotection against neuroapoptosis and neuro...

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Detalles Bibliográficos
Autores principales: WANG, YUJIE, WU, CHANGYI, HAN, BIN, XU, FEI, MAO, MINGFENG, GUO, XIANGYANG, WANG, JUN
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918603/
https://www.ncbi.nlm.nih.gov/pubmed/27222147
http://dx.doi.org/10.3892/mmr.2016.5321

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918603/
https://www.ncbi.nlm.nih.gov/pubmed/27222147
http://dx.doi.org/10.3892/mmr.2016.5321

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