A mutational signature in gastric cancer suggests therapeutic strategies

Targeting defects in the DNA repair machinery of neoplastic cells, for example, those due to inactivating BRCA1 and/or BRCA2 mutations, has been used for developing new therapies in certain types of breast, ovarian and pancreatic cancers. Recently, a mutational signature was associated with failure...

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Detalles Bibliográficos
Autores principales: Alexandrov, Ludmil B., Nik-Zainal, Serena, Siu, Hoi Cheong, Leung, Suet Yi, Stratton, Michael R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918743/
https://www.ncbi.nlm.nih.gov/pubmed/26511885
http://dx.doi.org/10.1038/ncomms9683

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918743/
https://www.ncbi.nlm.nih.gov/pubmed/26511885
http://dx.doi.org/10.1038/ncomms9683

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