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Mechanism of extracellular ion exchange and binding-site occlusion in the sodium-calcium exchanger
Na(+)/Ca(2+) exchangers utilize the Na(+) electrochemical gradient across the plasma membrane to extrude intracellular Ca(2+), and play a central role in Ca(2+) homeostasis. Here, we elucidate their mechanisms of extracellular ion recognition and exchange through a structural analysis of the exchang...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918766/ https://www.ncbi.nlm.nih.gov/pubmed/27183196 http://dx.doi.org/10.1038/nsmb.3230 |