The adenoviral E1A N-terminal domain represses MYC transcription in human cancer cells by targeting both p300 and TRRAP and inhibiting MYC promoter acetylation of H3K18 and H4K16

Human cancers frequently arise from increased expression of proto-oncogenes, such as MYC and HER2. Understanding the cellular pathways regulating the transcription and expression of proto-oncogenes is important for targeted therapies for cancer treatment. Adenoviral (Ad) E1A 243R (243 aa residues) i...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Ling-Jun, Loewenstein, Paul M., Green, Maurice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918948/
https://www.ncbi.nlm.nih.gov/pubmed/27382434
http://dx.doi.org/10.18632/genesandcancer.99

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918948/
https://www.ncbi.nlm.nih.gov/pubmed/27382434
http://dx.doi.org/10.18632/genesandcancer.99

Ejemplares similares