Reactivation of Endogenous Genes and Epigenetic Remodeling Are Barriers for Generating Transgene-Free Induced Pluripotent Stem Cells in Pig

Cellular reprogramming of committed cells into a pluripotent state can be induced by ectopic expression of genes such as OCT4, SOX2, KLF4, and MYC. Reprogrammed cells can be maintained by activating endogenous pluripotent networks without transgene expression. Although various research groups have a...

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Detalles Bibliográficos
Autores principales: Choi, Kwang-Hwan, Park, Jin-Kyu, Son, Dongchan, Hwang, Jae Yeon, Lee, Dong-Kyung, Ka, Hakhyun, Park, Joonghoon, Lee, Chang-Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918974/
https://www.ncbi.nlm.nih.gov/pubmed/27336671
http://dx.doi.org/10.1371/journal.pone.0158046

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918974/
https://www.ncbi.nlm.nih.gov/pubmed/27336671
http://dx.doi.org/10.1371/journal.pone.0158046

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