The Aberrant DNA Methylation Profile of Human Induced Pluripotent Stem Cells Is Connected to the Reprogramming Process and Is Normalized During In Vitro Culture

The potential clinical applications of human induced pluripotent stem cells (hiPSCs) are limited by genetic and epigenetic variations among hiPSC lines and the question of their equivalency with human embryonic stem cells (hESCs). We used MethylScreen technology to determine the DNA methylation prof...

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Detalles Bibliográficos
Autores principales: Tesarova, Lenka, Simara, Pavel, Stejskal, Stanislav, Koutna, Irena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919089/
https://www.ncbi.nlm.nih.gov/pubmed/27336948
http://dx.doi.org/10.1371/journal.pone.0157974

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919089/
https://www.ncbi.nlm.nih.gov/pubmed/27336948
http://dx.doi.org/10.1371/journal.pone.0157974

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