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Mechanism of Action and Clinical Application of Tafamidis in Hereditary Transthyretin Amyloidosis
Transthyretin (TTR) transports the retinol-binding protein–vitamin A complex and is a minor transporter of thyroxine in blood. Its tetrameric structure undergoes rate-limiting dissociation and monomer misfolding, enabling TTR to aggregate or to become amyloidogenic. Mutations in the TTR gene general...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Healthcare
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919130/ https://www.ncbi.nlm.nih.gov/pubmed/26894299 http://dx.doi.org/10.1007/s40120-016-0040-x |