Proteome-wide covalent ligand discovery in native biological systems

Small molecules are powerful tools for investigating protein function and can serve as leads for new therapeutics. Most human proteins, however, lack small-molecule ligands, and entire protein classes are considered “undruggable” (1,2). Fragment-based ligand discovery (FBLD) can identify small-molec...

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Detalles Bibliográficos
Autores principales: Backus, Keriann M., Correia, Bruno E., Lum, Kenneth M., Forli, Stefano, Horning, Benjamin D., González-Páez, Gonzalo E., Chatterjee, Sandip, Lanning, Bryan R., Teijaro, John R., Olson, Arthur J., Wolan, Dennis W., Cravatt, Benjamin F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919207/
https://www.ncbi.nlm.nih.gov/pubmed/27309814
http://dx.doi.org/10.1038/nature18002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919207/
https://www.ncbi.nlm.nih.gov/pubmed/27309814
http://dx.doi.org/10.1038/nature18002

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